GTBP

GTBP
(= G/T binding protein)
Protein (160 kD) important in mismatch recognition in human cells. The heterodimer of GTBP with hMSH2 (one of the MSH family) binds mismatches (G paired with T) as a first step in excision repair. Absence of either protein predisposes to tumours. GTBP gene is located near that for hMSH2 and GTBP can be considered one of the MSH family.

Dictionary of molecular biology. 2004.

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Look at other dictionaries:

  • MSH6 — MutS homolog 6 (E. coli) PDB rendering based on 2gfu …   Wikipedia

  • msh — Multigene family coding for proteins involved in mismatch repair. Homologous to S. cerevisiae MutS. Included in family are MSH1, MSH2, hMSH2, hMLH1, hPMS1, hPMS2 and probably GTBP …   Dictionary of molecular biology

  • RÉPARATION DE L’ADN — Mutations: lésions et réparation de l’ADN L’intégrité du matériel génétique présent dans toute cellule vivante sous forme d’acides nucléiques (et en premier lieu l’ADN, constitutif du génome) est continuellement remise en cause par de nombreux… …   Encyclopédie Universelle

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